Unfortunately, war is the daily media lead. We get the numbers of dead and injured for each conflict. You might consider those just injured as ‘lucky’ if you’re like me. Au contraire. Familiar issues are traumatic brain and spine injuries. Alongside lost limbs and wounds caused by bomb debris and emotional symptoms such as PTSD and depression that may persist for years, sometimes a lifetime. (Xaigham.com)
For life-saving technologies, war has unfortunately become a growth sector. I take no pleasure in saying that.
A sudden, traumatic blow to the spine (tSCI) can fracture, dislocate, crush or compress one or more of the vertebrae. A gunshot or knife wound that penetrates and cuts the spinal cord also can cause a spinal cord injury. Additional damage usually occurs over days or weeks.
The global Spinal Cord Trauma Treatment market was valued at US$ 2458.9 million in 2022 and is projected to reach US$ 3009.4 million by 2029, at a CAGR of 2.9% during the forecast period. The influence of COVID-19 and the Russia-Ukraine War were considered while estimating market sizes.
The current Middle East conflict was not included. Unfortunately, those projected growth numbers could rise significantly.
While I am using the wars and conflicts as examples of the growth of the traumatic injury market, it was already significant and this is just the US.
- A recent estimate of the annual incidence of traumatic spinal cord injury (CCI) is approximately 54 cases per one million people in the United States.
- The estimated number of people with tSCI living in the United States is approximately 302,000 persons, ranging from 255,000 to 383,000 persons.
- The average age at injury has increased from 29 during the 1970s to 43 since 2015.
- Traumatic brain injury (TBI) is defined as an alteration in brain function or other evidence of brain pathology caused by an external force. Examples of TBI include falls, assaults, motor vehicle accidents and sports injuries.
The question arises: how is this issue addressed? There are myriad companies, large and small, looking for answers.
TORONTO and HAIFA, Israel, Jan. 05, 2024 (GLOBE NEWSWIRE) — NurExone Biologic Inc. (TSXV: NRX) (FSE: J90) (NRX.V) (the “Company” or “NurExone”), a biopharmaceutical company developing biologically-guided exosome therapy for patients with traumatic spinal cord injuries.
How does it work? Stay with me; it’s pretty straightforward.
Part One: Active Ingredients
Exosomes: Exosomes, also known as extracellular vesicles, are nano-sized, naturally occurring particles in the body, secreted by cells. Exosomes, also known as extracellular vesicles, are nano-sized, naturally occurring particles in the body, secreted by cells. Can be administered non-invasively, intranasally
Part Two: Delivery
ExoTherapy: Exosomes, loaded with therapeutic molecules, cross the blood-brain barrier and reach cells and tissues for regeneration, rewiring and recovery.
Part Three: Effect
SiRNA-PTEN: The suggested PTEN inhibition-based therapeutic targets are nerve growth and regeneration after injury or damage, treatment of cardiac ischemia/reperfusion and associated disease, wound repair, and infertility.
The goal is to reverse this traumatic brain trauma as well as develop other health issues such as depression—no small accomplishment. The US FDA has granted NRX Orphan Drug Status.
The Orphan Drug Designation program provides orphan status to drugs and biologics for rare diseases that meet specific criteria. Orphan drug designation provides incentives, including:
- Tax credits for qualified clinical trials
- Exemption from user fees
- Potential for seven years of market exclusivity after approval
“Orphan-drug designation is expected to streamline our go-to-market, shorten our regulatory process, save the Company millions of dollars, and provide valuable market exclusivity. We appreciate the formal recognition of the potential impact of our therapy on the lives of patients suffering from acute spinal cord injuries,” said Dr. Shaltiel, CEO of NurExone Biologic, Ltd.
The Company also holds an exclusive worldwide license from Technion and Tel Aviv University for developing and commercializing the technology.
This technology is not only promising but appears well destined for success. In their totality, the current NRX out-front therapies could bring much relief to those seriously ‘injured’ patients who live with chronic pain and myriad challenges daily.
NurExome is a cutting-edge medical technology company. While trading has been modest, it paints a positive investment picture for the previously reasons stated. Will it pop tomorrow? No. That I can guarantee.
A savvy plan would to be to approach as a dollar-cost average investment. The deeper you dig, the more potential will become apparent.
Note Hyperlinks below.
| Stock stats Jan 5 2024 | |
| 52 Week Range | 0.1000 0.4200 |
| Volume | 7,000 |
| Avg. Volume | 4,511 |
| Market Cap | 14.475M |
| Beta (5Y Monthly) | N/A |
| PE Ratio (TTM) | N/A |
| EPS (TTM) | -0.1100 |
| Earnings Date | N/A |
| Forward Dividend & Yield | N/A (N/A) |
| Ex-Dividend Date | N/A |
| 1y Target Est | 4.01 |
| In-depth Corporate Presentation Litchfield Research |
AppYea (OTCQB: APYP) saw a lot of green on Wednesday. At 12:00 PM EST, the stock was traded at $0.0551 for a +35% gain and saw a high volume of 224k shares traded vs. 67k usually. What led to this leg up is AppYea announced it started to market its flagship product, DreamIT, an AI-based wristband to treat the snoring problem through biofeedback.
What is AppYea?
AppYea uses solutions based on its proprietary IP portfolio of AI and sensing technologies for tracking, analyzing, and diagnosing vital signs and other physical parameters during sleep time, offering extreme accuracy and resistance at an affordable cost. About the company’s background, it acquired SleepX in late December 2021.
“I am delighted that we have completed the acquisition of SleepX. The company develops a wearable technology solution to treat snoring and sleep apnea, which is patent protected in the US, EU, and Israel, and caters to two growing markets in high demand.”
Boris (Bary) Molchadsky, AppYea’s Chairman.
Now, the company announced it has completed the tests of the initial product version and plans to produce up to 20,000 units per month. DreamIT will be available to Android users, and deliveries of the first devices to customers will be expected to start by the end of the year.
How does DreamIT be performant? DreamIT uses a combined vibration motor and sensor system to measure real-time physiological data, including pulse, blood oxygen level, blood pressure, etc. Then, all these data are recorded in the SleepX phone app for analysis and storage. After, users can receive statistical reports on their sleep quality and health.
It is a solid technology because snoring has been found as the root of many issues. Among them, we can highlight exhaustion & fatigue, the lack of concentration, memory problems, the increased long-term risk for a stroke, a higher risk of heart disease and complications, chronic headache, etc. As you will understand, DreamIT can solve these issues for a better personal self. The product is drug-free and completely safe, avoiding the risk of ingesting toxins in an attempt to get a decent night’s sleep. Moreover, the product’s vibration gradually increases until the user’s respiration normalizes. No opposing sides, just positive effects!
The price of DreamIT for the consumer will be $149, and until the Christmas holidays, they can purchase it at a 33% discount at a sale price of only $99. You can order the product by clicking here.
Sector overview
Let’s focus first on the anti-snoring treatment market. Valued at USD $4.2B in 2020, the sector is expected to grow at a CAGR of 8.5% until 2027.
According to the American Sleep Association, approximately 50-70 million US adults have a sleep disorder, and out of those, 48% report snoring. Snoring is estimated to affect 40% of women and 57% of men. E-commerce will support the sector’s growth, combined with consumer adoption and sector awareness. The Covid-19 pandemic positively impacted the e-commerce segment, as numerous consumers opted to shop online as retail pharmacies needed to avoid indoor crowing. Another factor driving market adoption is the increased incidence of obese people and the adoption of an unhealthy lifestyle. The last factor buoying the sector is the presence of many players and favorable reimbursement policies, which also contribute to the growth of the anti-snoring treatment market.
Rising investment in research and development activities will introduce superior products in the market, further contributing to the industry revenue.
AppYea sees the growth opportunity and doesn’t want to miss the wagon wheel. Added to online marketing, the company intends to inter Amazon and work with distributors. Furthermore, the company is in discussions with a large Telecom company from Western Europe, a pharmacy chain store, and leading mattress manufacturers. But this is not just it! AppYea plans to contact leading smartphone manufacturers worldwide to offer the assimilation of its technology and rights to use its patent portfolio, which doesn’t stop growing. In the meantime, AppYea continues to develop additional algorithms and features that will reach users automatically through periodic version updates and continue improving SleepX PRO and DreamIT PRO for diagnosing and treating sleep apnea.
Stock Price
The company is currently traded at around USD $12M and saw a +27.70% close on Wednesday, 30. Investors were thrilled with the recount announcement, and more than 250k shares we traded, compared to the average of 67k. The company’s stock price is far from its 52-week low of $0.0002 but still has room to grow, as its 52-week high is worth $0.16. The company still has a lot of room to grow, and future sales will help the company to increase its stock price.
The company upgraded to the OTCQB in mid-October, enabling the company to get more visibility, and leaving the lowest-tier Pink Sheets. This venture market is the middle tier of the over-the-counter (OTC) market for US stocks.
Bottom Line
AppYea (OTCQB: APYP) is on track for the great year 2023. The company’s flagship product, DreamIT, is now marketed. New partnerships, combined with increased sales, will increase the company’s market cap. Let’s not forget sleeping/disorder treatments being more considered, connected to a more significant market awareness. So invest in the company, and why not buy the DreamIT product from the profits generated with the stock?
Marc has been involved in the Stock Market Media Industry for the last +4 years. After obtaining a college degree in engineering in France, he moved to Canada, where he created Money,eh?, a personal finance website. He then contributed to building Guerilla Capital, a Capital Markets company and FirstPhase Media where he is head of research. At10xAlerts, he writes articles and conducts interviews on many sectors, including technology, metals & mining markets.
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Marc CHALLANDEhttps://10xalerts.com/author/marcchallande/
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Marc CHALLANDEhttps://10xalerts.com/author/marcchallande/
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Marc CHALLANDEhttps://10xalerts.com/author/marcchallande/
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Marc CHALLANDEhttps://10xalerts.com/author/marcchallande/
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